Scientific web services produce and consume data in many different, loosely defined formats and messaging protocols. These heterogeneities make it especially difficult for services to be discovered and used in applications. This project aimed to address this problem by mapping components of a web service interface, such as input and output data elements and operations, to concepts in a well-defined and structured semantic model (i.e. ontology). This gives prospective consumers of a web service access to the service’s functionality even if they are unfamiliar with the specific syntax of its service interfaces. To demonstrate the advantages of attaching semantic meaning to scientific web services, I implemented a rudimentary proof of concept service by utilizing the latest versions of the Web Services Description Language (WSDL 2.0) and Semantic Annotations for WSDL (SAWSDL) standard recommendations, using the data exchange (NeXML), data semantics (CDAO), and data access (phyloWS) standards for phylogenetics recently developed by the NESCent EvoInfo Working Group.